I deal with treatment resistant Bipolar Disorder. I still take a combo of meds that make some days tolerable. I have been to several doctors to confirm that my doctor is right. I knew he was but my family was not accepting any of it. They still don’t. There are few ways to treat this. The biggest one is ECT or shock therapy. The patient has to have it 3 times a week for 6 weeks. More than half of those patients relapse within 6 months and have to go back for more. I have had it done once and found it extremely unpleasant. I also responded differently. I went into an extremely manic phase for awhile. After about a month I crashed. All of the other treatments have to do with some type of brain stimulation. Because I have memory and cognitive issues as it is the doctors are leary of doing them. Supposedly there is hope on the horizon with a new drug using Ketamine. It is I believe still in it’s trial stage but is said to relieve depression within 5 minutes. I would sell some body parts for that kind of relief, that is if I had any healthy ones. But hope is a strange thing, as long as you still have it you can keep fighting no matter what anyone else does or says.